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Target intelligence / Profile preview
Integrin beta-4 (ITGB4)
- Target
- ITGB4
- Molecular classification
- Integrin, Cell adhesion receptor, Transmembrane glycoprotein
01
Overview
Integrin beta-4 (ITGB4) is a transmembrane glycoprotein that functions as a subunit of the integrin family of cell adhesion receptors. It exclusively pairs with the alpha 6 subunit to form the α6β4 integrin heterodimer. This heterodimer plays a critical structural role in hemidesmosomes, anchoring epithelial cells to the underlying basement membrane. Beyond structural support, integrin β4 mediates signal transduction from the extracellular matrix into intracellular pathways, influencing cell proliferation, migration, and invasion. Mutations in ITGB4 cause epidermolysis bullosa with pyloric atresia, while overexpression or altered function contributes to tumorigenesis.
- Other names
- CD104β4 integrin subunit
02
Mechanism of action
Not applicable
03
Biological functions
Cell adhesionSignal transductionCell proliferationCell migrationCell invasionActin cytoskeleton organizationHemidesmosome formation
04
Disease associations
Epidermolysis bullosa with pyloric atresia (EB–PA)Cancer
05
Safety considerations
Targeting may disrupt normal epithelial function.Potential for off-target effects due to widespread expression.
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