Target intelligence / Profile preview

Integrin Beta 6 (IB6)

Target: IB6
Molecular classification: Integrin, Receptor, Transmembrane glycoprotein

Overview

Integrin beta 6 (IB6), also known as integrin subunit beta 6 or ITGB6, is a protein that forms a heterodimer exclusively with the alpha v subunit to create the integrin αvβ6 receptor. Integrins are transmembrane glycoproteins that mediate cell adhesion and signal transduction between the extracellular matrix (ECM) and intracellular environment. It acts as a receptor for ECM proteins and plays a critical role in cell adhesion, migration, and signal transduction affecting cell behavior. Overexpression is linked to aggressive disease progression and poor prognosis across several carcinomas and is involved in TGF-beta activation, which can suppress antitumor immune responses.

Other names: ITGB6Integrin subunit beta 6AI1Hαvβ6

Mechanism of action

Antibody-drug conjugate (ADC) targeting IB6 for selective tumor cell killing through MMAE toxin delivery

Biological functions

Cell adhesionCell migrationSignal transductionExtracellular matrix interactionTGF-beta activation

Disease associations

CancerWound healingAmelogenesis imperfecta

Safety considerations

Potential for off-target effects due to integrin expression in normal tissues (although normally low)Toxicities associated with MMAE payload in ADCs

Interacting drugs

Sigvotatug vedotin (SGN-B6A)

Biomarkers

IB6 expression levels in tumor tissue

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