Target intelligence / Profile preview

Integrin-linked kinase (ILK)

Target: ILK
Molecular classification: Pseudo-serine/threonine kinase, Scaffold protein, Adaptor protein

Overview

Integrin-linked kinase (ILK) is a multifunctional protein that plays a central role in integrin-mediated signal transduction, acting as both a scaffold and signaling molecule at sites of cell–matrix adhesion. It regulates key cellular processes including cell adhesion, migration, proliferation, survival, differentiation, and cytoskeletal organization. ILK is implicated in various diseases, including cancer and cardiomyopathies.

Biological functions

Cell-matrix signal transductionFocal adhesion assemblyCytoskeleton organizationCell adhesionCell migrationCell proliferationCell survivalCell differentiation

Disease associations

CancerCardiomyopathy

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