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Target intelligence / Profile preview
Integrin Mac-1 (Mac-1)
- Target
- Mac-1
- Molecular classification
- Integrin, Receptor, Cell adhesion molecule
01
Overview
Integrin Mac-1, also known as macrophage-1 antigen, is a multifunctional cell surface receptor with critical roles in immune cell adhesion, migration, and signaling. It is a heterodimeric transmembrane protein composed of CD11b (αM subunit) and CD18 (β2 subunit). Mac-1 mediates leukocyte recruitment to sites of inflammation, phagocytosis of opsonized particles, and modulates inflammatory gene expression. It is expressed on neutrophils, monocytes/macrophages, dendritic cells, and osteoclast progenitors. Dysregulation of Mac-1 has been implicated in autoimmune diseases and chronic inflammatory conditions.
- Other names
- Macrophage-1 antigenintegrin αMβ2CD11b/CD18Complement receptor 3 (CR3)
02
Mechanism of action
Modulation of leukocyte adhesion, migration, and activation
03
Biological functions
AdhesionMigrationPhagocytosisSignal transductionImmune responseRegulation of inflammatory gene expressionNegative regulation of TLR signalingSuppression of B cell receptor signalingModulation of T cell/dendritic cell activity
04
Disease associations
Autoimmune diseasesChronic inflammatory conditionsBone remodeling disorders
05
Safety considerations
Aberrant leukocyte traffickingExcessive inflammationDysregulation of immune homeostasis
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