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Target intelligence / Profile preview
Integrin Receptor (N/A)
- Target
- N/A
- Molecular classification
- Receptor, Transmembrane receptor
01
Overview
Integrins are a large family of heterodimeric transmembrane receptors that mediate cell adhesion to the extracellular matrix (ECM) and facilitate cell–cell interactions. They are composed of alpha (α) and beta (β) subunits and play critical roles in cell adhesion, migration, proliferation, survival, and mechanotransduction. Dysregulation is implicated in diseases such as cancer metastasis, thrombosis, and inflammation. Therapeutic strategies focus on blocking ligand binding or interfering with activation.
- Other names
- Cell adhesion receptorExtracellular matrix receptor
02
Mechanism of action
Blocking ligand binding sites or interfering with activation/conformational change mechanisms.
03
Biological functions
Cell adhesionCell migrationCell proliferationCell survivalSignal transductionMechanotransductionImmune responseAngiogenesis
04
Disease associations
Cancer metastasisThrombosisFibrosisAutoimmune disordersChronic inflammationCardiovascular disease
05
Safety considerations
Potential for off-target effects due to broad expression of integrinsRisk of bleeding complications (for anti-thrombotic integrin inhibitors)Immunogenicity of monoclonal antibody therapiesDevelopment of resistance
06
Interacting drugs
Monoclonal antibodies against integrins
3 more in the full profile.
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