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Target intelligence / Profile preview
Integrin Subunit Alpha 1 (ITGA1)
- Target
- ITGA1
- Molecular classification
- Integrin, Receptor, Cell adhesion molecule
01
Overview
Integrin subunit alpha 1, also known as CD49a, forms part of the integrin family of cell surface receptors that mediate cell-extracellular matrix (ECM) and cell-cell interactions. Specifically, integrin alpha-1 pairs with the beta-1 subunit to form the α1β1 integrin heterodimeric receptor. It acts as a receptor for collagens and laminins, playing a role in cell adhesion, migration, proliferation, and signal transduction. Dysregulation is linked to cancer and inflammatory conditions.
- Other names
- CD49aVLA-1Very Late Antigen 1
02
Mechanism of action
Integrin α1β1 acts as a receptor for collagens (notably types I and IV) and laminins in the ECM, mediating cell adhesion and signal transduction.
03
Biological functions
Cell-matrix adhesionSignal transductionCell migrationCell proliferationCell differentiationCell survivalImmune responseT cell motility
04
Disease associations
CancerRheumatoid arthritisInflammation
05
Safety considerations
Potential for off-target effects due to broad expression in various tissues.Dysregulation can lead to abnormal tissue remodeling.
06
Biomarkers
CD49a expression levels in T cells
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