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Target intelligence / Profile preview
Integrin Subunit Alpha 4 (ITGA4)
- Target
- ITGA4
- Molecular classification
- Integrin, Cell adhesion molecule, Receptor
01
Overview
ITGA4, also known as Integrin Subunit Alpha 4 or CD49d, is an integrin alpha subunit that forms heterodimeric integral membrane proteins by associating with either beta 1 (forming α4β1) or beta 7 (forming α4β7) chains. It plays crucial roles in cell adhesion, migration, immune system regulation, and developmental processes. ITGA4 is a therapeutic target in cancer and inflammatory conditions, with antagonists like Carotegrast methyl being developed.
- Other names
- CD49d
02
Mechanism of action
ITGA4 antagonist
03
Biological functions
Cell adhesionCell migrationLeukocyte tetheringLeukocyte rollingLeukocyte migrationImmune responseB cell differentiationImmune cell traffickingHeart developmentBlood vessel remodelingAxonogenesisCell-cell adhesionCell surface adhesionSignaling
04
Disease associations
CancerInflammationAutoimmune diseases
05
Safety considerations
Potential for immunosuppressionOff-target effects on other integrin-mediated processes
06
Interacting drugs
Carotegrast methyl
07
Biomarkers
C-reactive proteinCarbohydrate antigen 125
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