Integrin subunit alpha 5 mRNA (ITGA5 mRNA)

Integrin subunit alpha 5 (ITGA5) mRNA encodes the alpha 5 subunit of the integrin alpha-5/beta-1 heterodimer, which serves as the primary cellular receptor for fibronectin (UniProt P08648). This receptor is a critical mediator of cell-matrix interactions, regulating essential processes such as cell adhesion, migration, proliferation, and survival (NCBI Gene 3678). In various pathological states, particularly in solid tumors like glioblastoma and ovarian cancer, ITGA5 mRNA is significantly overexpressed, driving epithelial-mesenchymal transition (EMT), metastasis, and tumor-associated angiogenesis (PMID: 31235647). Targeting ITGA5 at the mRNA level using small interfering RNAs (siRNAs) or antisense oligonucleotides (ASOs) provides a therapeutic strategy to silence the gene before protein synthesis occurs (PMID: 28651314). This approach aims to disrupt the oncogenic signaling pathways and vascular remodeling associated with high ITGA5 expression. While protein-targeting agents like monoclonal antibodies have been investigated, mRNA-targeted therapies offer the potential for more complete inhibition of the receptor's function in the disease microenvironment.

Other names

Integrin alpha-5 mRNACD49e mRNAVLA-5 alpha subunit mRNAFibronectin receptor alpha subunit mRNAFNRA mRNAAntigen CD49E mRNA

Degradation of ITGA5 mRNA via RNA interference (siRNA) or antisense-mediated RNase H cleavage, resulting in the knockdown of Integrin alpha-5 protein expression and inhibition of fibronectin-mediated signaling.