Integrin subunit alpha 6 (ITGA6)

Integrin subunit alpha 6 is a cell-surface protein encoded by the ITGA6 gene. It functions as part of two major heterodimeric integrin receptors: alpha-6/beta-4, which is critical for the structural stability of epithelia and forms hemidesmosomes anchoring the epidermis, and alpha-6/beta-1, implicated in developmental tissue morphogenesis[1][2][4][6][7]. Both heterodimers act as receptors for laminins, mediating cell-matrix adhesion, signal transduction, and regulation of cell proliferation, survival, and migration[1][4][6][7]. Alterations in integrin alpha-6 expression or function are linked to several pathological states, including carcinoma progression and rare genetic skin disorders, underscoring its dual importance in tissue integrity and as a potential therapeutic target[2][4][5].

Other names

Integrin alpha-6CD49fVLA-6 (when heterodimerized with beta-1)TSP180 (when heterodimerized with beta-4)ITGA6 gene product

Inhibition of cell adhesion and migration by blocking the interaction between integrin alpha-6 and its ligands (e.g., laminins) Disruption of signaling pathways involved in metastasis and proliferation (preclinical research)