Integrin subunit alpha D (ITGAD)

Integrin subunit alpha D (ITGAD), also known as CD11d, is a member of the beta-2 integrin family of membrane glycoproteins. It partners with the common β2 chain (CD18) to form the αDβ2 integrin receptor, which is predominantly expressed on myeloid lineage cells such as monocytes, macrophages, dendritic cells, and polymorphonuclear leukocytes[1][2][4]. Integrin αDβ2 mediates cell adhesion and migration by binding to cell surface ligands including ICAM-3 and VCAM-1, and is involved in outside-in signaling that promotes inflammatory gene expression and chemokine/cytokine production. It plays key roles in modulating innate immune responses, particularly in chronic inflammation, and contributes to macrophage fusion in inflammatory environments[1][6]. While ITGAD is recognized as a valid immunological and potential therapeutic target, it is not currently targeted by any approved drugs.

Other names

CD11dADB2integrin alpha-Dleukointegrin alpha Dintegrin αDCD11 antigen-like family member Dbeta-2 integrin alphaD subunitItgax

Inhibitors (when developed) would block cell adhesion and migration via integrin αDβ2, attenuating immune cell infiltration and inflammatory processes[6].