Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Integrin subunit alpha M (ITGAM)
- Target
- ITGAM
- Molecular classification
- Integrin, Receptor
01
Overview
Integrin alpha M (ITGAM), also known as CD11b or Mac-1 alpha subunit, forms a heterodimer with integrin beta 2 (CD18) to create the functional receptor αMβ2 or Mac-1/CR3. This receptor is expressed on leukocytes and plays a crucial role in immune responses by mediating cell adhesion, migration, phagocytosis, and complement activation. It binds to ligands such as iC3b, fibrinogen, Factor X, and ICAM-1. Genetic variants in ITGAM are associated with autoimmune diseases like systemic lupus erythematosus. It's commonly used as a marker for myeloid lineage cells in immunohistochemistry.
- Other names
- CD11bMac-1 alpha subunitCR3AComplement receptor 3 (CR3)Macrophage-1 antigen (Mac-1)
02
Mechanism of action
Modulation of integrin-mediated cell adhesion and signaling
03
Biological functions
Cell adhesionCell migrationPhagocytosisInflammationComplement activationImmune responseChemotaxisCell-mediated cytotoxicity
04
Disease associations
Systemic lupus erythematosusInflammationInfection
Beyond the preview
Go deeper on Integrin subunit alpha M (ITGAM).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Integrin subunit alpha M (ITGAM).