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Integrin Subunit Beta 1 (ITGB1)
- Target
- ITGB1
- Molecular classification
- Integrin, Transmembrane protein, Cell surface receptor
01
Overview
Integrin subunit beta 1 (ITGB1 or CD29) is a transmembrane protein that forms part of the integrin family, which are heterodimeric cell surface receptors. ITGB1 can pair with multiple alpha subunits, resulting in different receptor complexes with unique tissue distributions and functions. It plays a central role in cell adhesion, bidirectional signal transduction, and regulation of key cellular processes including proliferation, apoptosis, migration, and motility. Dysregulation or mutation can impact development/tissue integrity or promote disease states such as cancer metastasis.
- Other names
- CD29Fibronectin receptor beta subunitVLA-4 subunit betaIntegrin beta-1
02
Mechanism of action
Modulation of cell adhesion and signaling pathways via interactions with extracellular matrix proteins and other integrin subunits.
03
Biological functions
Cell adhesionSignal transductionCell proliferationApoptosisCell migrationWound healingImmune responseHemostasisAngiogenesisBone formationMuscle developmentExtracellular matrix organization
04
Disease associations
Cancer metastasisDevelopmental disordersTissue integrity disordersPlacental disorders
05
Safety considerations
Potential for off-target effects due to broad expression and multiple binding partnersDysregulation can lead to unwanted cell growth and metastasisPotential for affecting normal tissue repair processes
06
Biomarkers
ITGB1 expression levels in tumor tissueITGB1 isoform expression in muscle tissueITGB1 expression on immune cells
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