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Target intelligence / Profile preview
Integrin subunit beta 7 (ITGB7)
- Target
- ITGB7
- Molecular classification
- Integrin, Cell adhesion molecule, Transmembrane protein, Receptor
01
Overview
Integrin subunit beta 7 (ITGB7) is a transmembrane protein that forms heterodimers with alpha integrin subunits, primarily α4 (CD49d) or αE (CD103). The α4β7 integrin interacts with MAdCAM-1 on endothelial cells to direct lymphocyte homing to gut-associated lymphoid tissue. The αEβ7 integrin interacts with E-cadherin on epithelial cells to mediate retention of lymphocytes within epithelial tissues. ITGB7 plays a critical role in leukocyte adhesion, migration, and immune surveillance at mucosal surfaces, and is a therapeutic target for inflammatory bowel disease and other immune-mediated disorders.
- Other names
- Gut homing receptor β subunitIntegrin β-PM290 IEL antigenLy69
02
Mechanism of action
Inhibition of ITGB7 prevents lymphocyte binding to MAdCAM-1 and/or E-cadherin, thereby blocking lymphocyte trafficking to mucosal tissues and reducing inflammation.
03
Biological functions
Cell adhesionCell migrationLymphocyte homingImmune cell traffickingImmune responseSignal transduction
04
Disease associations
Inflammatory Bowel DiseaseT-cell Non-Hodgkin LymphomaMultiple MyelomaInflammationImmune dysregulation
05
Safety considerations
Potential for immunosuppressionIncreased risk of infection
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