Inter-alpha-trypsin inhibitor heavy chain 5 (ITIH5)

Inter-alpha-trypsin inhibitor heavy chain 5 (ITIH5) is a member of the inter-alpha-trypsin inhibitor (ITI) protein family, which consists of plasma proteins involved in the stabilization of the extracellular matrix and protection against tumor metastasis[3][4]. ITIH5 encodes a heavy chain subunit that combines with the bikunin light chain to form complexes participating in extracellular matrix biology[1][2]. This protein is predominantly expressed in plasma and is thought to function as a tumor suppressor, particularly in breast and thyroid cancers, by inhibiting protease activity and maintaining matrix integrity[3][4]. It is part of a broader family of proteins (including ITIH1-4) whose heavy chains may interact with hyaluronic acid in various physiological and pathological processes, including inflammation, wound healing, and potentially regulation of tumor progression[1][2]. **Note:** There are no approved drugs directly targeting ITIH5 as of the latest evidence, and its primary significance lies in cancer biology and extracellular matrix regulation rather than as a pharmacologic receptor or enzyme in the conventional sense[3][4].

Other names

ITIH5Inter-alpha-inhibitor H5Inter-alpha-trypsin inhibitor H5Plasma protease C3a inhibitor family member 5

No specific mechanisms established for direct drug targeting; ITIH5 is thought to exert tumor suppressor effects by stabilizing extracellular matrix and inhibiting protease-mediated matrix degradation[3][4]