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Target intelligence / Profile preview
Inter-alpha-trypsin inhibitor heavy chain family member 6 (ITIH6)
- Target
- ITIH6
- Molecular classification
- Other, Extracellular matrix-associated protein, Protease inhibitor (as a family function; not a direct function for this heavy chain)
01
Overview
Inter-alpha-trypsin inhibitor heavy chain family member 6 (ITIH6) is a protein encoded by the ITIH6 gene and is a member of the inter-alpha-trypsin inhibitor heavy chain (ITIH) family. This family is characterized by its function in the extracellular matrix, where the heavy chain subunits (including ITIH6) mediate protein-protein interactions and contribute to matrix stabilization. Unlike the light chain subunit, which carries protease inhibitor activity, ITIH6 primarily participates in structural roles within the matrix. Mutations or dysregulation of ITIH6 have been associated with specific diseases such as atrial septal defect 9 and familial hyperinsulinemic hypoglycemia. However, there is currently no evidence that ITIH6 serves as a direct therapeutic target or interacts with pharmaceuticals[1][2][8].
- Other names
- Inter-alpha-trypsin inhibitor heavy chain H6ITIH5LUNQ6369PRO21074Inter-alpha inhibitor H5-like proteindJ14O9.1ITI-like protein
02
Biological functions
Mediates protein-protein interactions in the extracellular matrixContributes to structural stabilization of the extracellular matrix
03
Disease associations
Atrial septal defect 9Hyperinsulinemic hypoglycemia, familial, 7Other (potentially cancer and tissue remodeling based on broader ITIH family function)
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