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Target intelligence / Profile preview
Inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3)
- Target
- ITIH3
- Molecular classification
- Other (Extracellular matrix protein), Protease inhibitor family, Acute phase protein
01
Overview
Inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) is an extracellular matrix protein, belonging to the protease inhibitor family and functioning as an acute phase protein. It plays crucial roles in the stabilization and assembly of the extracellular matrix, binding to hyaluronic acid, and modulating inflammation and immune responses. ITIH3 acts as a carrier of hyaluronan in serum and inhibits serine-type endopeptidases. It has been implicated in various disease states, including cardiovascular disease, cancer, inflammatory conditions, psychiatric disorders, and sepsis. Although ITIH3 has biomarker potential, particularly for rheumatoid arthritis, no specific drugs are currently known to interact with or directly target ITIH3.
- Other names
- Inter-alpha-trypsin inhibitor heavy chain 3ITIH3ITI heavy chain H3ITI-HC3Serum-derived hyaluronan-associated proteinSHAPH3 polypeptidePre-alpha (globulin) inhibitor H3Inter-alpha (globulin) inhibitor H3
02
Mechanism of action
Not applicable; no approved drugs directly target ITIH3.
03
Biological functions
Stabilization of extracellular matrixBinding to hyaluronic acidRegulation of inflammation and immune responseExtracellular matrix assembly and maintenanceCarrier of hyaluronan in serumInhibition of serine-type endopeptidases
04
Disease associations
Cardiovascular disease (myocardial infarction, atherosclerosis)Cancer (various human solid tumors)Inflammatory diseases (rheumatoid arthritis, inflammatory bowel diseases)Psychiatric disorders (schizophrenia, major depressive disorder, autism spectrum disorder)Sepsis
05
Interacting drugs
None known/specific described in literature; no direct drug interactions are currently established
06
Biomarkers
Early detection biomarker for rheumatoid arthritisGenetic polymorphisms associated
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