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Target intelligence / Profile preview
Interactor of HORMAD1 protein 1 (IHO1)
- Target
- IHO1
- Molecular classification
- Other (coiled-coil domain-containing protein), Chromatin-associated meiotic regulator, Cancer/testis antigen (potential biomarker classification)
01
Overview
Interactor of HORMAD1 protein 1 (IHO1) is a coiled-coil domain-containing protein conserved across vertebrates and primarily expressed in testis tissue where it plays a critical role in meiotic recombination[2][4][9]. It forms homotetramers through a parallel four-stranded coiled-coil region and scaffolds the assembly of the MEI4–REC114–IHO1 (MCD) recombinosome complex on chromatin during meiosis[4][8]. IHO1 interacts directly with chromosome axis protein HORMAD1 to seed DSB machinery clusters, thereby enabling DNA double-strand break formation necessary for correct homologous chromosome pairing[2][3][6]. Disruption of IHO1 function or expression leads to meiotic failure and infertility but is not known to be modulated by drugs. As a cancer/testis antigen, IHO1 has potential as a biomarker for tumor subtypes with aberrant testis-like gene expression profiles[9].
- Other names
- CCDC36CT74FLJ25320LELA1Cancer/testis antigen 74Coiled-coil domain-containing protein 36
02
Biological functions
Promotion of meiotic DNA double-strand break formation (DSB) in unsynapsed chromosome regionsAssembly and scaffolding of the MCD (MEI4-REC114-IHO1) recombinosome complexChromatin localization and platform formation for recombination machinery
03
Disease associations
Cancer (as a cancer/testis antigen, IHO1 is indexed in CT antigen databases and is testis-enriched with abnormal expression documented in some tumors)Other (essential for meiosis, infertility if mutated or absent)
04
Biomarkers
Cancer/testis antigen (IHO1 may serve as a tissue specificity biomarker due to its expression pattern, but not established for clinical diagnostics)Testis-enriched expression marker for spermatocyte staging and infertility research
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