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Target intelligence / Profile preview
Intercellular Adhesion Molecule 1 (ICAM-1)
- Target
- ICAM-1
- Molecular classification
- Immunoglobulin superfamily, Transmembrane protein, Glycoprotein, Receptor
01
Overview
Intercellular adhesion molecule 1 (ICAM-1), also known as CD54, is a cell surface glycoprotein and member of the immunoglobulin superfamily. It acts as an adhesion receptor for β2 integrins, facilitating leukocyte rolling and transmigration. ICAM-1 participates in intracellular signaling pathways and contributes to immunological synapse formation. It also serves as an entry receptor for certain pathogens. Soluble ICAM-1 (sICAM-1) can modulate leukocyte binding. ICAM-1 is implicated in numerous pathological conditions and serves as a marker for inflammation.
- Other names
- CD54
02
Mechanism of action
Modulation of inflammation or immune cell trafficking (attempted, limited success)
03
Biological functions
Leukocyte adhesionLeukocyte migrationSignal transductionImmunological synapse formationPathogen entry
04
Disease associations
Cardiovascular diseasesAutoimmune disordersInfectionsMalariaCancerInflammationPsychiatric disorders
05
Safety considerations
Limited success of clinical interventions targeting ICAM-1
06
Biomarkers
sICAM-1 (inflammation marker)
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