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Target intelligence / Profile preview
Intercellular Matrix Proteins (Stratum Corneum) (SC Intercellular Matrix Proteins)
- Target
- SC Intercellular Matrix Proteins
- Molecular classification
- Structural Protein, Extracellular Matrix Protein
01
Overview
The intercellular matrix of the stratum corneum (SC) is a specialized extracellular environment between corneocytes, crucial for maintaining the skin’s barrier function and hydration. It's composed of lipids (ceramides, free fatty acids, cholesterol) and structural proteins (involucrin, loricrin, filaggrin, SPRs). These components form lamellar bilayers and cross-linked protein envelopes, providing a strong permeability barrier, mechanical strength, and protection against pathogens. Covalent linkage between lipids and structural proteins is critical for barrier integrity.
- Other names
- Stratum Corneum Matrix ProteinsCorneocyte Envelope ProteinsInvolucrinLoricrinFilaggrinSmall Proline Rich Proteins (SPR)
02
Biological functions
Barrier functionHydrationMechanical strengthAntimicrobial defenseCell adhesion
03
Disease associations
EczemaPsoriasisIchthyosisAtopic DermatitisSkin Barrier Dysfunction
04
Safety considerations
Barrier disruption can lead to increased drug absorption
05
Biomarkers
Filaggrin mutations (Atopic Dermatitis)
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