Interferon alpha 12 pseudogene (IFNA12P)

Interferon alpha 12 pseudogene (IFNA12P) is a nonfunctional genetic sequence in the mouse genome related to the family of type I interferons. Unlike protein-coding interferon alpha genes, IFNA12P contains in-frame stop codons and mutations typical of pseudogenes, preventing translation of a functional interferon protein[1][2][3]. It does not participate in immune modulation, signaling, or antiviral activity characteristic of active type I interferons[2][3]. There is no evidence of biological activities, therapeutic relevance, or drug interactions associated with IFNA12P, and its presence is primarily noted in the context of comparative genomics and gene family evolution[2][3]. Key Points: - IFNA12P is a pseudogene, not a protein-coding gene or a functional therapeutic target[1][2][3]. - It does not encode a receptor, enzyme, transporter, or other targetable molecule[1][2][3]. - There are at least 14 IFN-alpha genes and 3 IFN-alpha pseudogenes in the mouse; IFNA12P is one of the pseudogenes[2][3]. - The pseudogene status indicates loss of biological activity and loss of significance for therapy or diagnostics[1][2][3].

Other names

IFN-alpha12 pseudogeneMuIFN-alpha12 pseudogeneIFN-α12Pinterferon alpha-12, pseudogene