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Target intelligence / Profile preview
Interferon alpha 2 (IFNα2)
- Target
- IFNα2
- Molecular classification
- Cytokine, Type I Interferon
01
Overview
Interferon alpha2 (IFNα2) is a cytokine belonging to the type I interferon family. It is produced and secreted by cells, particularly leukocytes, in response to viral infection. IFNα2 plays a crucial role in the innate immune response by inhibiting viral replication and modulating immune cell activity.
- Other names
- IFNa2IFN-alpha 2bIFN-alphaIFN-ainterferon alfa
02
Mechanism of action
Binds type I interferon receptors (IFNAR1 and IFNAR2) → activates JAK/STAT pathway → induces expression of interferon-stimulated genes (ISGs) leading to antiviral state and immunomodulation.
03
Biological functions
Antiviral defenseImmunomodulationDirect inhibition of viral replicationEnhancement of natural killer cell functionModulation of adaptive immunityAnti-proliferative effects
04
Disease associations
Chronic hepatitis B & C infectionsHairy cell leukemiaFollicular lymphomaMalignant melanomaAIDS-related Kaposi's sarcomaInfectionCancer
05
Interacting drugs
Interferon alfa-2b (Intron A)
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