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Target intelligence / Profile preview
Interferon alpha-2b (IFNA2B)
- Target
- IFNA2B
- Molecular classification
- Cytokine, Type I Interferon
01
Overview
IFNA2B encodes interferon alpha-2b, a type I interferon cytokine that plays a central role in the innate immune response against viral infections and has significant antitumor properties. It binds to the IFNAR1/IFNAR2 receptor complex, activating the JAK-STAT signaling pathway and inducing the expression of interferon-stimulated genes (ISGs). Therapeutically, recombinant IFNA2B and pegylated forms are used to treat viral infections and certain cancers.
- Other names
- Interferon alfa-2bIFNA2
02
Mechanism of action
Binds to IFNAR1/IFNAR2 receptor complex, activates JAK-STAT pathway, induces ISG expression
03
Biological functions
Antiviral activityImmunomodulationAntiproliferative activityApoptosis inductionJAK-STAT signaling
04
Disease associations
Chronic hepatitis BChronic hepatitis CHairy cell leukemiaMalignant melanomaFollicular lymphomaAIDS-related Kaposi's sarcomaViral infection
05
Safety considerations
Flu-like symptoms (fever/chills/myalgia)Depression/suicidal ideationCytopenias
06
Interacting drugs
Interferon alfa-2b (recombinant)
1 more in the full profile.
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