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Target intelligence / Profile preview
Interferon alpha/beta receptor 1
- Molecular classification
- Receptor, Type I cytokine receptor
01
Overview
Interferon alpha/beta receptor 1 (IFNAR1) is a type I membrane protein and one of two essential subunits of the receptor complex for type I interferons, including interferons alpha and beta. The IFNAR complex is virtually ubiquitous, present on most cell types, and mediates cellular responses to endogenous type I interferon cytokines. Upon binding to a type I interferon, the two subunits come together to form an active signaling complex, activating the JAK/STAT pathway and leading to antiviral responses, inhibition of cell proliferation, and modulation of immune activity.
02
Mechanism of action
Binding of type I interferons (IFN-alpha or IFN-beta) to IFNAR1 and IFNAR2 leads to receptor dimerization and activation of the JAK/STAT pathway.
03
Biological functions
Signal transductionAntiviral responsesInhibition of cell proliferationModulation of immune activity
04
Disease associations
InfectionCancerAutoimmune diseases
05
Safety considerations
Rapid downregulation of surface-expressed IFNAR1 following ligand exposure.Species specificity in signal transduction.
06
Interacting drugs
1 more in the full profile.
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