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Target intelligence / Profile preview
Interferon alpha/beta receptor subunit 2 (IFNAR2)
- Target
- IFNAR2
- Molecular classification
- Receptor, Type I cytokine receptor, Type II helical cytokine receptors, Transmembrane protein
01
Overview
IFNAR2 is a type I transmembrane protein and a subunit of the heterodimeric receptor for type I interferons. It plays a crucial role in initiating cellular responses to viral infections and modulating the immune system. Upon binding type I interferons, IFNAR2, along with IFNAR1, activates the JAK-STAT signaling pathway, leading to the expression of interferon-stimulated genes (ISGs).
02
Mechanism of action
Agonism (via interferon binding leading to receptor activation and downstream signaling)
03
Biological functions
Signal transductionAntiviral responseRegulation of innate immunityImmune responseCell growth inhibitionJAK-STAT signaling pathway
04
Disease associations
Viral infectionsAutoimmune diseases
05
Safety considerations
Potential for immune-related adverse events due to broad immune modulation
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