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Target intelligence / Profile preview
Interferon Beta (IFN-beta)
- Target
- IFN-beta
- Molecular classification
- Cytokine, Type I Interferon, Immunomodulator
01
Overview
Interferon beta is a type I interferon cytokine with immunomodulatory properties, primarily used to treat multiple sclerosis. It acts by binding to IFNAR1 and IFNAR2 receptors, activating the JAK/STAT pathway and inducing the expression of numerous immunomodulatory genes, resulting in reduced inflammation in the central nervous system and prevention of nerve damage.
- Other names
- IFNBFibroblast interferonInterferon beta-1aInterferon beta-1b
02
Mechanism of action
Immunomodulation via JAK/STAT pathway activation through IFNAR1/IFNAR2
03
Biological functions
Immune response regulationAntiviral activityModulation of T cell activityModulation of B cell activityModulation of antigen-presenting cell activityUpregulation of MHC class I expression
04
Disease associations
Multiple SclerosisAutoimmune disease
05
Safety considerations
Flu-like symptomsInjection-site reactionsDepressionLiver enzyme elevations
06
Interacting drugs
Interferon beta-1a
1 more in the full profile.
07
Biomarkers
Neopterin2'-5' oligoadenylate synthetaseProtein kinase R
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