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Interferon-gamma (None)
- Target
- None
- Molecular classification
- Cytokine, Type II Interferon
01
Overview
Interferon-gamma (IFN-γ) is a dimerized, soluble cytokine and the only member of the type II class of interferons. It is primarily produced by immune cells such as T helper 1 (Th1) cells, cytotoxic T lymphocytes, natural killer (NK) cells, macrophages, and mucosal epithelial cells. IFN-γ plays a central role in both innate and adaptive immunity due to its broad immunoregulatory, antiviral, antibacterial, and antitumor properties.
- Other names
- IFN-γIFNG
02
Mechanism of action
Binds to heterodimeric cell-surface receptor complex (IFNGR1 and IFNGR2), triggering JAK/STAT pathway activation and subsequent gene transcription.
03
Biological functions
ImmunoregulationAntiviral defenseAntibacterial defenseAntitumor defenseNK cell activationAntigen presentationMacrophage activationiNOS activationMHC upregulationCellular trafficking/migrationInhibition of cellular proliferationApoptosis controlMicrobicidal effector function activation
04
Disease associations
Chronic granulomatous diseaseOsteopetrosisAntitumor therapyJuvenile rheumatoid arthritisChemoresistant pulmonary tuberculosisIdiopathic pulmonary fibrosisAtypical mycobacterial infectionsInfection
05
Interacting drugs
Interferon-gamma
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