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Target intelligence / Profile preview
Interferon-gamma-producing T cell (IFN-γ-producing T cell)
- Target
- IFN-γ-producing T cell
- Molecular classification
- Lymphocyte, T cell subset, Cytokine-producing cell
01
Overview
Interferon-gamma (IFN-γ)-producing T cells are a subset of lymphocytes, primarily including CD4+ T helper type 1 (Th1) cells and CD8+ cytotoxic T lymphocytes, that secrete the cytokine IFN-γ upon activation. These cells play a central role in orchestrating immune responses against intracellular pathogens and tumors by producing IFN-γ, which has broad immunomodulatory effects.
- Other names
- IFN-gamma T cellInterferon gamma positive T cellTh1 cellsCytotoxic T lymphocytes (CTLs) producing IFN-γ
02
Mechanism of action
N/A - Cells themselves, not a molecular target
03
Biological functions
Immune responseAntiviral immunityAntitumor immunityMacrophage activationAdaptive immunityRegulation of immune responsesT cell differentiation
04
Disease associations
Infectious diseaseCancerAutoimmunityInflammation
05
Safety considerations
Overproduction can lead to autoimmunity or tissue damage.Deficiency can lead to increased susceptibility to infections.Potential for cytokine storm
06
Interacting drugs
IL-12
5 more in the full profile.
07
Biomarkers
IFN-γ levelsNumber of IFN-γ-producing T cellsT-bet expression
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