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Target intelligence / Profile preview
Interferon gamma receptor 1 (IFNGR1)
- Target
- IFNGR1
- Molecular classification
- Type II cytokine receptors, Receptor, CD119
01
Overview
Interferon gamma receptor 1 (IFNGR1), also known as CD119, is the ligand-binding alpha chain of the heterodimeric interferon-gamma (IFNγ) receptor complex. It is a type II cytokine receptor essential for triggering downstream signaling pathways involved in antimicrobial, antiviral, and antitumor immune responses. Upon binding IFNγ, IFNGR1 initiates a JAK/STAT signaling cascade that activates immune response genes.
- Other names
- CD119CDw119IFN-gamma-R-alphaIFN-gamma-R1Interferon gamma receptor alpha-chain
02
Mechanism of action
Not applicable; IFNGR1 is the receptor, not the drug. Drugs targeting the IFNGR1 pathway would likely aim to modulate its activity (e.g., agonists to enhance signaling, antagonists to block it).
03
Biological functions
Signal transductionImmune responseAntimicrobial responseAntiviral responseAntitumor responseAntigen presentation
04
Disease associations
ImmunodeficiencyInfectionMycobacterial InfectionsTuberculosisAtypical Mycobacteriosis
05
Safety considerations
Modulation of IFNGR1 signaling can have broad effects on the immune system, potentially leading to autoimmunity or increased susceptibility to other infections.Mutations in IFNGR1 can cause severe immunodeficiency.
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