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Target intelligence / Profile preview
Interferon gamma receptor 2 (IFNGR2)
- Target
- IFNGR2
- Molecular classification
- Type II cytokine receptor family, Receptor
01
Overview
Interferon gamma receptor 2 (IFNGR2) is a critical component of the interferon-gamma (IFN-γ) receptor complex. It is the non-ligand-binding beta chain and plays an essential role in immune signaling and host defense by enabling signal transduction through the JAK/STAT pathway. Mutations in IFNGR2 cause autosomal recessive Mendelian susceptibility to mycobacterial disease (MSMD).
- Other names
- AF-1IFGR2IFNGT1IMD28interferon gamma transducer 1interferon gamma receptor beta chain
02
Mechanism of action
Enables signal transduction via JAK/STAT pathway upon interferon-gamma binding to IFNGR1.
03
Biological functions
Signal transductionImmune responseHost defense
04
Disease associations
Mendelian susceptibility to mycobacterial disease (MSMD)InfectionImmunodeficiency
05
Safety considerations
Mutations can lead to increased susceptibility to mycobacterial infections.
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