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Target intelligence / Profile preview
Interferon-induced 2′–5′ adenylate synthetase (OAS)
- Target
- OAS
- Molecular classification
- Enzyme
01
Overview
Interferon-induced 2′–5′ adenylate synthetase (OAS) is a family of enzymes that play a central role in the innate immune response to viral infections. Induced by interferons and activated by double-stranded RNA, OAS enzymes synthesize 2-5A oligomers, which in turn activate RNase L to degrade viral and cellular RNA, inhibiting virus replication. OAS enzymes also participate in apoptosis regulation and growth control.
- Other names
- 2'-5'-oligoadenylate synthetase2-5A synthetase
02
Mechanism of action
OAS enzymes are induced by interferons and activated by dsRNA, catalyzing the synthesis of 2-5A oligomers from ATP. These oligomers activate RNase L, leading to RNA degradation and inhibition of viral replication.
03
Biological functions
Antiviral defenseApoptosis regulationGrowth controlImmune response
04
Disease associations
Viral InfectionsCancerAutoimmune Diseases
05
Safety considerations
Over-activation can lead to excessive RNA degradation and cellular damagePotential for off-target effects on cellular RNA metabolism
06
Interacting drugs
Interferons
1 more in the full profile.
07
Biomarkers
OAS1 expression levelsOAS2 expression levelsOAS3 expression levels2-5A levelsRNase L activity
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