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Target intelligence / Profile preview
Interferon-induced helicase C domain-containing protein 1 (IFIH1)
- Target
- IFIH1
- Molecular classification
- Pattern Recognition Receptor, Helicase, Intracellular receptor
01
Overview
Interferon-induced helicase C domain-containing protein 1 (IFIH1), also known as MDA5, is a cytoplasmic pattern recognition receptor that detects viral double-stranded RNA (dsRNA). Upon binding dsRNA, MDA5 activates the innate immune system, triggering the production of type I interferons and other inflammatory cytokines. Dysregulation of IFIH1 has been linked to several autoimmune diseases.
- Other names
- MDA5Helicard
02
Mechanism of action
Directly binds viral dsRNA, triggering downstream signaling cascades including type I interferon production.
03
Biological functions
Innate antiviral responseInterferon signalingInflammation regulationdsRNA sensingImmune response
04
Disease associations
Type 1 Diabetes MellitusSystemic Lupus ErythematosusAutoimmune thyroiditisPsoriasisSingleton-Merten SyndromeAicardi-Goutieres SyndromeViral Infection
05
Safety considerations
Overactivation of IFIH1 can lead to excessive interferon production and autoimmune disorders.Potential for off-target effects when developing therapeutics that target IFIH1.
06
Biomarkers
rs1990670 (SNP; potential biomarker for autoimmunity)IFIH1 expression levels in SLE (disease activity)Genetic variants in IFIH1 (disease risk)
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