Interferon-induced transmembrane protein 10 (IFITM10)

Interferon-induced transmembrane protein 10 (IFITM10) is a member of the dispanin family of proteins, structurally related to, but functionally distinct from, canonical IFITMs (such as IFITM1-3). IFITM10 is predicted to be located in the plasma membrane and may play roles in cellular processes beyond the classical antiviral defense associated with other IFITMs. Unlike IFITM1/2/3, IFITM10 lacks key interferon-stimulated response elements and is not robustly induced by interferons, suggesting divergent regulatory mechanisms. IFITM10 shows tissue-specific expression, notably in smooth muscle, esophagus, and trachea. Elevated expression has been linked to favorable early diagnosis in gastric cancer, and the CTSD-IFITM10 fusion has been identified in breast cancer, indicating possible functions in tumorigenesis or as a biomarker. Diminished expression is correlated with impaired immune responses in certain viral infections, but overall, IFITM10 remains poorly characterized, with no clear mechanistic information or established role as a therapeutic target.

Other names

IFITM10Dispanin subfamily A member 3DSPA3Interferon-induced transmembrane protein 10

No mechanism of drug action is defined for IFITM10, as it is not an established or characterized drug target