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Interferon lambda 4 pseudogene 1 (IFNL4P1)
- Target
- IFNL4P1
- Molecular classification
- Cytokine (Type III interferon family), Pseudogene
01
Overview
The designation **interferon lambda 4 pseudogene 1 (IFNL4P1)** refers to a *pseudogene* variant of the **Interferon lambda 4 (IFNL4)** gene, which encodes a type III interferon cytokine involved in epithelial immune responses to viral infection. Human populations segregate alleles at this locus—one (ΔG) can produce functional IFNL4 protein, the other (TT) results in a nonfunctional pseudogene due to frameshift mutation and nonsense-mediated mRNA decay. The functional IFNL4 is linked to antiviral immunity and regulation of interferon-induced genes, but its presence has paradoxically been associated with decreased clearance of hepatitis C virus. "IFNL4P1" specifically refers to the non-functional, pseudogenized variant and is not a therapeutic target, nor is it a standard subject in clinical drug development. The molecular roles, mechanisms, and disease relevance center on the **active IFNL4 gene/protein**, not its pseudogene.
- Other names
- IFNL4Interferon lambda 4IL28BDeltaG
02
Mechanism of action
Not applicable for IFNL4P1; for IFNL4: triggers antiviral response through JAK-STAT signaling and interferon-stimulated genes.
03
Biological functions
Immune response (specifically in response to viral infection, via antiviral signaling)Signal transduction (JAK-STAT pathway activation)
04
Disease associations
Infection (role in hepatitis C virus clearance/persistence)
05
Safety considerations
None specific to IFNL4P1; for IFNL4, its expression has paradoxically been associated with impaired clearance of HCV
06
Biomarkers
Genetic variants in/near IFNL4 (e.g., rs12979860, ss469415590, rs8099917) serve as biomarkers for hepatitis C virus clearance and responsiveness to treatment
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