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Target intelligence / Profile preview
Interferon Lambda Receptor (IFN-λR)
- Target
- IFN-λR
- Molecular classification
- Receptor, Cytokine Receptor, Type III Interferon Receptor, Heterodimeric Receptor
01
Overview
The Interferon Lambda Receptor (IFN-λR) is a heterodimeric cell surface receptor complex that mediates the biological effects of type III interferons (IFN-λs). It consists of the IFNLR1 subunit (unique to IFN-λs) and the IL10RB subunit (shared with other cytokine receptors). Activation of the receptor leads to antiviral defense, immune modulation, and regulation of inflammation, particularly at mucosal surfaces.
- Other names
- IFNLRType III Interferon Receptor
02
Mechanism of action
Activation of JAK1 and TYK2 kinases, leading to phosphorylation and activation of STAT proteins (STAT1/STAT2) and induction of interferon-stimulated genes (ISGs).
03
Biological functions
Signal transductionAntiviral activityImmunomodulationRegulation of cellular proliferationRegulation of inflammation
04
Disease associations
InfectionInflammation
05
Safety considerations
Potential for immune-related adverse eventsTissue-specific expression may limit systemic efficacy
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