Interferon regulatory factor 4 (IRF4)

Interferon regulatory factor 4 (IRF4) is a transcription factor belonging to the IRF family, primarily expressed in immune cells. It plays a central role in regulating gene expression during immune cell development and function, particularly within lymphoid and myeloid lineages. Its functions include B and T cell differentiation, myeloid lineage commitment, and regulation of Toll-like receptor signaling pathways. Dysregulation of IRF4 has been implicated in various diseases, including lymphoid malignancies and autoimmune disorders.

Binds ISRE sequences on target genes either alone or together with cofactors like PU.1 or BATFs depending on the context. Influences gene regulation through homo/hetero-dimerization.