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Target intelligence / Profile preview
Interferon-Stimulated Gene Pathway (ISG Pathway)
- Target
- ISG Pathway
- Molecular classification
- Signaling Pathway
01
Overview
The interferon-stimulated gene (ISG) pathway is a critical component of the innate immune response, activated primarily by interferons (IFNs). When IFNs bind to their respective cell surface receptors, they trigger intracellular signaling cascades that lead to the transcriptional activation of hundreds of ISGs. These genes encode proteins with diverse functions, including antiviral defense, modulation of immune responses, and regulation of cell proliferation.
- Other names
- Interferon Signaling PathwayIFN-Stimulated Gene Pathway
02
Mechanism of action
Activation of JAK-STAT signaling, transcriptional activation of ISGs
03
Biological functions
Antiviral defenseImmunomodulationRegulation of cell proliferationApoptosis
04
Disease associations
InfectionAutoimmune diseasesInflammationCancerInterferonopathies
05
Safety considerations
Overactivation leading to harmful inflammationPotential for autoimmune side effects
06
Interacting drugs
Interferons (IFN-α, IFN-β, IFN-γ, IFN-λ)
1 more in the full profile.
07
Biomarkers
ISG expression levelsIFN levels
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