Interferon-stimulated non-coding RNA 1 (INCR1)

Interferon-stimulated non-coding RNA 1 (INCR1) is a long noncoding RNA (lncRNA) transcribed from the PD-L1 locus, which is upregulated in response to interferon gamma (IFNγ) signaling. INCR1 modulates tumor immune evasion by binding to the nuclear ribonucleoprotein HNRNPH1, thereby inhibiting its suppressive effect on neighboring genes PD-L1 and JAK2, resulting in increased expression of these immunosuppressive molecules. Knockdown of INCR1 reduces PD-L1 and JAK2 expression, enhances the susceptibility of tumor cells to T cell-mediated cytotoxicity, and improves outcomes with CAR T cell therapy. INCR1 is considered a promising therapeutic target for cancer immunotherapy due to its key role in tumor immune evasion[1][2][4][6].

Other names

IFN-stimulated noncoding RNA 1lncRNA INCR1

Modulation of RNA-binding protein (HNRNPH1) activity, leading to increased expression of immunosuppressive molecules PD-L1 and JAK2