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Target intelligence / Profile preview
Interleukin 1 (IL-1)
- Target
- IL-1
- Molecular classification
- Cytokine
01
Overview
Interleukin-1 refers primarily to two distinct but related proteins: IL-1α and IL-1β. Both are potent proinflammatory cytokines produced mainly by macrophages during defensive reactions. The IL-1 family consists of 11 structurally similar cytokines (including IL-18, IL-33, and others), all involved in regulating or controlling inflammation. Excessive or uncontrolled activity is linked with various pathologies including autoimmune diseases; therapeutic blockade using recombinant antagonists or antibodies has proven effective in some human disorders.
- Other names
- IL1IL-1αIL-1β
02
Mechanism of action
Therapeutic blockade using recombinant antagonists or antibodies competing for binding to the receptor.
03
Biological functions
InflammationImmune response regulationDevelopment of adaptive immunityInnate immunity
04
Disease associations
Autoimmune diseasesChronic inflammatory conditionsAutoinflammatory diseases
05
Safety considerations
Excessive or uncontrolled activity linked with various pathologies.
06
Interacting drugs
Recombinant antagonists
1 more in the full profile.
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