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Target intelligence / Profile preview
Interleukin 1 alpha (IL-1α)
- Target
- IL-1α
- Molecular classification
- Cytokine, Interleukin
01
Overview
Interleukin 1 alpha (IL-1α) is a pro-inflammatory cytokine belonging to the interleukin 1 family. It plays a central role in mediating immune and inflammatory responses, as well as hematopoiesis. Both the precursor and mature forms of IL-1α are bioactive, and it can function intracellularly and extracellularly. Due to its potent activity initiating inflammation, dysregulation of IL–l α has been implicated in several major human diseases and is considered an important drug target for anti-inflammatory therapies under development.
- Other names
- Hematopoietin 1Fibroblast-activating factor (FAF)Lymphocyte-activating factor (LAF)B-cell activating factor (BAF)Leukocyte endogenous mediator (LEM)Epidermal cell-derived thymocyte activating factor (ETAF)Serum amyloid A inducer or hepatocyte-stimulating factor (HSP)CatabolinHemopoetin‑1 (H‑1)Endogenous pyrogen (EP)Proteolysis-inducing factor (PIF)
02
Mechanism of action
Inhibition of IL-1α signaling
03
Biological functions
Pro-inflammatory signalingImmune system regulationHematopoiesisCell proliferationBone resorption
04
Disease associations
Autoimmune disordersChronic inflammatory conditionsCancer progressionFever syndromesSepsis
05
Safety considerations
Potential for broad immunosuppressionIncreased risk of infection
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