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Target intelligence / Profile preview
Interleukin 1 Family Member (IL-1)
- Target
- IL-1
- Molecular classification
- Cytokine, Interleukin, Receptor, Ligand
01
Overview
The Interleukin-1 (IL-1) family is a group of cytokines that play a central role in the regulation of immune and inflammatory responses. IL-1 is a key mediator of innate immunity and inflammation, with its family members involved in both proinflammatory and anti-inflammatory processes. Dysregulation contributes to autoinflammatory diseases. The family consists of 11 cytokines including agonists (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ), receptor antagonists (IL-1Ra, IL-36Ra, and IL-38), and an anti-inflammatory cytokine (IL-37).
- Other names
- IL1 FamilyIL-1 FamilyInterleukin-1 FamilyIL1
02
Mechanism of action
Block IL-1 receptor signaling, neutralize IL-1 ligands
03
Biological functions
Immune responseInflammationCell signalingLeukocyte recruitmentHost defenseTranscriptional activation
04
Disease associations
Autoinflammatory diseasesRheumatoid arthritisSystemic lupus erythematosusInflammationInfection
05
Safety considerations
Increased risk of infectionInjection site reactionsNeutropenia
06
Interacting drugs
IL-1Ra (Anakinra)
1 more in the full profile.
07
Biomarkers
IL-1 levelsInflammatory markers (e.g., CRP, ESR)
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