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Target intelligence / Profile preview
Interleukin 1 Receptor Accessory Protein (IL1RAP)
- Target
- IL1RAP
- Molecular classification
- Receptor, Immunoglobulin superfamily
01
Overview
Interleukin 1 Receptor Accessory Protein (IL1RAP) is an essential co-receptor for several interleukin receptors, including IL1R1, IL-33 receptor, and IL-36 receptor. It mediates immune responses via cytokine-induced inflammation and participates in both innate and adaptive immunity. Aberrant activation of IL1RAP pathways contributes to autoimmune disorders, chronic inflammatory conditions, neurodegenerative diseases, fibrotic diseases, and cancer. It is being explored as a therapeutic target for eliminating malignant cells.
- Other names
- IL-1RAcPCD121bIL-1 receptor accessory protein
02
Mechanism of action
Monoclonal antibodies against IL1RAP block IL-1, IL-33, and IL-36 signaling.
03
Biological functions
Immune responseInflammatory signalingCytokine signalingSynapse formation
04
Disease associations
Autoimmune disordersChronic inflammatory conditionsNeurodegenerative diseasesFibrotic diseasesCancer
05
Safety considerations
Potential for broad immunosuppression due to targeting multiple cytokine pathways.
06
Biomarkers
IL1RAP expression in gliomasIL1RAP expression in pediatric acute lymphoblastic leukemia
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