Interleukin-1 receptor accessory protein (IL1RAP) mRNA (IL1RAP mRNA)

Interleukin-1 receptor accessory protein (IL1RAP) mRNA encodes a transmembrane protein that is a vital component of the IL-1 receptor complex (UniProt Q9NPH3). It functions as a co-receptor for IL-1, IL-33, and IL-36, facilitating signal transduction through the NF-kappa-B and MAPK pathways (PubMed: 22837413). In hematological malignancies like acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), IL1RAP is highly expressed on leukemic stem cells but not on normal hematopoietic stem cells, making it a specific target for therapy (PubMed: 20855605). Targeting the mRNA transcript via RNA interference (siRNA) or antisense oligonucleotides (ASOs) allows for the selective knockdown of IL1RAP protein production, potentially inhibiting the growth of malignant clones (PubMed: 28232571). This approach aims to disrupt the pro-inflammatory and survival signaling that drives cancer progression and resistance. While most clinical-stage drugs currently target the IL1RAP protein (e.g., Nadunolimab), mRNA-targeted strategies are being explored in preclinical models to achieve more complete or intracellular inhibition. Safety considerations include the potential for systemic suppression of innate immune signaling and the challenges associated with the targeted delivery of nucleic acid therapeutics to the bone marrow or tumor microenvironment.

Other names

IL-1RAcP mRNAIL1R3 mRNAC3orf13 mRNAInterleukin-1 receptor 3 mRNA

RNA interference and antisense-mediated mRNA degradation