Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1)

Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of the interleukin-1 receptor family distinguished by its selective and high expression in the brain. Unlike canonical interleukin-1 receptor accessory proteins that mediate immune or inflammatory signaling, IL1RAPL1 does not participate in immune signaling but instead plays an essential role in nervous system development by organizing synapse formation and neuronal connectivity. Mutations or deletions in the IL1RAPL1 gene are causative for X-linked intellectual disability and may also contribute to neurodevelopmental disorders such as autism. The protein contains three immunoglobulin (Ig)-like domains in its extracellular region and is also known as Oligophrenin-4[2][6][7]. It mediates trans-synaptic cell adhesion and is critical for normal synaptic function and neural signaling in the human brain.

Other names

IL-1RAPL1IL1RAPL-1IL-1-RAPL-1Oligophrenin-4Three immunoglobulin domain-containing IL-1 receptor family member

Not applicable, as there are no drugs directly targeting this protein. Gene loss or mutation results in loss of function in neural synapse organization, but no targeted pharmacological mechanism is established[7].