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Target intelligence / Profile preview
Interleukin 1 receptor antagonist (IL‑1Ra)
- Target
- IL‑1Ra
- Molecular classification
- Interleukin 1 cytokine family, Cytokine, Antagonist
01
Overview
Interleukin 1 receptor antagonist (IL‑1Ra) is a natural inhibitor of interleukin-1 (IL-1) signaling. It binds to IL-1 receptors without inducing signal transduction, thereby blocking the pro-inflammatory effects of IL-1α and IL-1β. Deficiency leads to autoinflammatory diseases. Recombinant human IL-1Ra is used therapeutically as an anti-inflammatory agent.
- Other names
- IL1RN
02
Mechanism of action
Binds to cell surface interleukin-1 receptors with high affinity, preventing IL-1α/β binding and subsequent signal transduction.
03
Biological functions
Immune responseInhibition of IL-1 signalingAnti-inflammatory activity
04
Disease associations
InflammationAutoimmune diseasesAutoinflammatory diseases
05
Safety considerations
Large excess of IL‑1Ra may be needed therapeutically due to low occupancy needed by agonists to trigger cellular activation.
06
Interacting drugs
Recombinant human IL‑1Ra (Anakinra)
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