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Target intelligence / Profile preview
Interleukin-1 receptor-associated kinase 3 (IRAK3)
- Target
- IRAK3
- Molecular classification
- Serine/threonine-specific protein pseudokinase
01
Overview
IRAK3 is a member of the interleukin-1 receptor-associated kinase family, primarily expressed in myeloid cells. It functions as a negative regulator of innate immune signaling pathways downstream of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1R). Unlike other IRAK family members, IRAK3 is considered a pseudokinase and inhibits TLR and IL-1R signaling by stabilizing the Myddosome complex, preventing activation of downstream kinases. It is involved in tumor progression, asthma, and sepsis.
- Other names
- IRAK-M
02
Mechanism of action
Functions via scaffolding/stabilization to suppress TLR/IL‑1R → Myddosome → NFκB/MAPK/ERK
03
Biological functions
Negative regulation of immune signalingRegulation of TLR/IL-1R signaling pathwaysModulation of inflammationMyddosome stabilization
04
Disease associations
CancerAsthmaChronic InflammationSepsisEndotoxin response
05
Safety considerations
Potential for broad immunosuppression if targeted inappropriatelyComplex roles in inflammation require careful consideration of context
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