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Target intelligence / Profile preview
Interleukin 1 Receptor-Like 1 Protein (IL1RL1)
- Target
- IL1RL1
- Molecular classification
- Receptor, Interleukin-1 receptor family, Toll-like receptor superfamily
01
Overview
Interleukin 1 receptor-like 1 (IL1RL1), also known as ST2, is a receptor belonging to the interleukin-1 receptor family. It exists in two main isoforms: a membrane-bound form (ST2L) that functions as a cell surface receptor for interleukin-33 (IL-33), and a soluble form (sST2) that acts as a decoy for IL-33. The IL-33/ST2 signaling pathway plays important roles in regulating immune responses, particularly in allergic inflammation and asthma, and has significant effects on cardiac tissue, where it can mediate cardioprotective effects. Soluble ST2 is a biomarker for heart failure.
- Other names
- ST2
02
Mechanism of action
sST2 acts as a decoy receptor, binding IL-33 and preventing it from interacting with membrane-bound ST2L, thus inhibiting downstream signaling.
03
Biological functions
Immune responseSignal transductionInflammationCardioprotection
04
Disease associations
AsthmaAllergic InflammationRheumatoid ArthritisHeart FailureCardiac Stress
05
Safety considerations
Blocking IL-33/ST2 signaling may have unintended consequences in cardiac protectionModulating immune responses requires careful consideration to avoid immune suppression or hyperactivation.
06
Biomarkers
sST2 levels in blood (prognostic biomarker for heart failure/cardiac stress)IL1RL1 genetic variants (associated with asthma susceptibility)
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