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Target intelligence / Profile preview
Interleukin 1 Receptor Type I (IL1R1)
- Target
- IL1R1
- Molecular classification
- Receptor, Interleukin-1 receptor family, Immunoglobulin superfamily
01
Overview
Interleukin 1 Receptor Type I (IL1R1) is a transmembrane receptor that binds interleukin-1α (IL-1α) and interleukin-1β (IL-1β). Upon ligand binding, it forms a complex with IL-1RAP (IL-1R3) to activate intracellular signaling pathways, including NF-kappa-B and MAPK, leading to the expression of pro-inflammatory genes. IL1R1 plays a critical role in initiating and amplifying inflammatory responses.
- Other names
- CD121aIL-1RαIL-1RTI
02
Mechanism of action
IL-1RA blocks the binding of IL-1α and IL-1β to IL1R1, preventing downstream signaling.
03
Biological functions
Signal transductionImmune responseInflammation initiationCostimulation for IFN-gamma production
04
Disease associations
InflammationAutoimmune diseasesInfection
05
Safety considerations
Potential for immunosuppression
06
Interacting drugs
Interleukin 1 receptor antagonist (IL-1RA)
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