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Target intelligence / Profile preview
Interleukin-10 Receptor
- Molecular classification
- Type II Cytokine Receptor, Receptor
01
Overview
The Interleukin-10 receptor (IL-10R) is a type II cytokine receptor that mediates the biological effects of interleukin-10 (IL-10), a key anti-inflammatory cytokine. IL-10R plays a crucial role in regulating immune responses, particularly by limiting and terminating inflammatory processes. It is a tetrameric complex composed of two α subunits (IL-10R1/IL10RA) and two β subunits (IL-10R2/IL10RB). Upon ligand binding, JAK1 and TYK2 kinases activate STAT3, driving transcription of anti-inflammatory genes. Defects can result in severe early-onset IBD. It is explored as a therapeutic target for autoimmune diseases, tissue damage repair, and cancer immunotherapy modulation.
- Other names
- IL-10RIL10RIL-10 Receptor complex
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Mechanism of action
Modulation of IL-10 signaling pathway
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Biological functions
Signal transductionImmune responseAnti-inflammatory signalingRegulation of immune responses
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Disease associations
InflammationAutoimmune diseasesInflammatory bowel disease (IBD)Cancer
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Safety considerations
Potential for immunosuppressionRisk of infection
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