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Target intelligence / Profile preview
Interleukin 10 Receptor Alpha (IL10RA)
- Target
- IL10RA
- Molecular classification
- Type I membrane protein, Receptor
01
Overview
Interleukin 10 Receptor Alpha (IL10RA) is the high-affinity ligand-binding subunit of the interleukin-10 (IL-10) receptor complex, which mediates the immunosuppressive effects of IL-10. Upon binding to IL-10, IL10RA initiates downstream signaling cascades, primarily through the JAK/STAT pathway, leading to the suppression of pro-inflammatory cytokines and the promotion of anti-inflammatory gene expression. Defects in IL10RA are associated with severe early-onset inflammatory bowel disease.
- Other names
- CD210CD210aCDW210AHIL-10RIL-10R1Interleukin 10 Receptor Subunit Alpha
02
Mechanism of action
Agonism or antagonism of IL-10 signaling via the IL-10 receptor complex.
03
Biological functions
Ligand bindingSignal transductionImmune responseAnti-inflammatory signalingRegulation of cytokine production
04
Disease associations
Inflammatory bowel disease (IBD)Chronic inflammatory diseasesCancer
05
Safety considerations
Potential for immune suppression leading to increased susceptibility to infections.Potential for dysregulation of immune responses contributing to cancer development or progression.
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