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Interleukin 10 Receptor Alpha Subunit
- Molecular classification
- Type II cytokine receptor family, Receptor
01
Overview
The interleukin 10 receptor alpha subunit (IL10RA) is the ligand-binding component of the interleukin-10 (IL-10) receptor complex. It mediates immunosuppressive signals from IL-10 by inhibiting the synthesis of proinflammatory cytokines, promoting survival of myeloid progenitor cells, and downregulating MHCII and costimulatory molecules on dendritic cells/macrophages. Defects or mutations in IL10RA are linked to early-onset inflammatory bowel disease. It also plays a role in tumor immunity.
- Other names
- IL10RACD210CD210aIL-10R1CDW210AHIL-10R
02
Mechanism of action
Agonism via IL-10 binding, leading to JAK-STAT pathway activation and downstream gene expression changes.
03
Biological functions
Signal transductionImmune responseAnti-inflammatory responseRegulation of cytokine productionMaintenance of intestinal mucosal homeostasis
04
Disease associations
Inflammatory bowel diseaseCancer
05
Safety considerations
Potential for immunosuppressionDysregulation can lead to inflammatory disorders
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